Found 77 hits with Last Name = 'domanico' and Initial = 'pl' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50029954
((7R,7aS)-7-(3-Cyclopentyloxy-4-methoxy-phenyl)-hex...)Show SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CCN2[C@@H]1CNC2=O Show InChI InChI=1S/C18H24N2O3/c1-22-16-7-6-12(10-17(16)23-13-4-2-3-5-13)14-8-9-20-15(14)11-19-18(20)21/h6-7,10,13-15H,2-5,8-9,11H2,1H3,(H,19,21)/t14-,15-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 4B |
J Med Chem 38: 4848-54 (1996)
BindingDB Entry DOI: 10.7270/Q2DZ079X |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50048248
((3S,4R)-3-Acetyl-4-(3-cyclopentyloxy-4-methoxy-phe...)Show SMILES COC(=O)N1C[C@H]([C@@H](C1)c1ccc(OC)c(OC2CCCC2)c1)C(C)=O Show InChI InChI=1S/C20H27NO5/c1-13(22)16-11-21(20(23)25-3)12-17(16)14-8-9-18(24-2)19(10-14)26-15-6-4-5-7-15/h8-10,15-17H,4-7,11-12H2,1-3H3/t16-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50285059
(1-(tert-butyl) 3-methyl 4-(3-cyclopentyloxy-4-meth...)Show SMILES COC(=O)[C@@H]1CN(C[C@H]1c1ccc(OC)c(OC2CCCC2)c1)C(=O)OC(C)(C)C Show InChI InChI=1S/C23H33NO6/c1-23(2,3)30-22(26)24-13-17(18(14-24)21(25)28-5)15-10-11-19(27-4)20(12-15)29-16-8-6-7-9-16/h10-12,16-18H,6-9,13-14H2,1-5H3/t17-,18+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470745
(CHEMBL286840)Show SMILES COc1ccc(cc1OC1CCCC1)C1CCN(C1)C(=O)OC(C)(C)C Show InChI InChI=1S/C21H31NO4/c1-21(2,3)26-20(23)22-12-11-16(14-22)15-9-10-18(24-4)19(13-15)25-17-7-5-6-8-17/h9-10,13,16-17H,5-8,11-12,14H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470752
(CHEMBL38328)Show SMILES COc1ccc(cc1OC1CCCC1)C1CCN(C1)C(=O)Oc1ccccc1 Show InChI InChI=1S/C23H27NO4/c1-26-21-12-11-17(15-22(21)27-19-9-5-6-10-19)18-13-14-24(16-18)23(25)28-20-7-3-2-4-8-20/h2-4,7-8,11-12,15,18-19H,5-6,9-10,13-14,16H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50285045
(1-isopropyl 3-methyl 4-(3-cyclopentyloxy-4-methoxy...)Show SMILES COC(=O)[C@@H]1CN(C[C@H]1c1ccc(OC)c(OC2CCCC2)c1)C(=O)OC(C)C Show InChI InChI=1S/C22H31NO6/c1-14(2)28-22(25)23-12-17(18(13-23)21(24)27-4)15-9-10-19(26-3)20(11-15)29-16-7-5-6-8-16/h9-11,14,16-18H,5-8,12-13H2,1-4H3/t17-,18+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470756
(CHEMBL37453)Show InChI InChI=1S/C20H29NO4/c1-3-12-24-20(22)21-11-10-16(14-21)15-8-9-18(23-2)19(13-15)25-17-6-4-5-7-17/h8-9,13,16-17H,3-7,10-12,14H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50285042
(CHEMBL302632 | tert-butyl 3-(3-cyclopentyloxy-4-me...)Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CN(C[C@H]1CO)C(=O)OC(C)(C)C Show InChI InChI=1S/C22H33NO5/c1-22(2,3)28-21(25)23-12-16(14-24)18(13-23)15-9-10-19(26-4)20(11-15)27-17-7-5-6-8-17/h9-11,16-18,24H,5-8,12-14H2,1-4H3/t16-,18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50285038
(1-benzyl 3-methyl 4-(3-cyclopentyloxy-4-methoxyphe...)Show SMILES COC(=O)[C@@H]1CN(C[C@H]1c1ccc(OC)c(OC2CCCC2)c1)C(=O)OCc1ccccc1 Show InChI InChI=1S/C26H31NO6/c1-30-23-13-12-19(14-24(23)33-20-10-6-7-11-20)21-15-27(16-22(21)25(28)31-2)26(29)32-17-18-8-4-3-5-9-18/h3-5,8-9,12-14,20-22H,6-7,10-11,15-17H2,1-2H3/t21-,22+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470750
(CHEMBL286291)Show InChI InChI=1S/C22H28N2O3/c1-23-12-5-8-19(23)22(25)24-13-11-17(15-24)16-9-10-20(26-2)21(14-16)27-18-6-3-4-7-18/h5,8-10,12,14,17-18H,3-4,6-7,11,13,15H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470731
(CHEMBL146946)Show SMILES COC(=O)N1CC[C@@H](C1)c1ccc(OC)c(OC2CCCC2)c1 Show InChI InChI=1S/C18H25NO4/c1-21-16-8-7-13(11-17(16)23-15-5-3-4-6-15)14-9-10-19(12-14)18(20)22-2/h7-8,11,14-15H,3-6,9-10,12H2,1-2H3/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470736
(CHEMBL37029)Show SMILES COc1ccc(cc1OC1CCCC1)C1CCN(C1)C(=O)OCc1ccccc1 Show InChI InChI=1S/C24H29NO4/c1-27-22-12-11-19(15-23(22)29-21-9-5-6-10-21)20-13-14-25(16-20)24(26)28-17-18-7-3-2-4-8-18/h2-4,7-8,11-12,15,20-21H,5-6,9-10,13-14,16-17H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50285050
(CHEMBL59386 | methyl 3-(3-cyclopentyloxy-4-methoxy...)Show SMILES COC(=O)N1C[C@H]([C@@H](C1)[N+]([O-])=O)c1ccc(OC)c(OC2CCCC2)c1 Show InChI InChI=1S/C18H24N2O6/c1-24-16-8-7-12(9-17(16)26-13-5-3-4-6-13)14-10-19(18(21)25-2)11-15(14)20(22)23/h7-9,13-15H,3-6,10-11H2,1-2H3/t14-,15+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50029955
((7R,7aR)-7-(3-Cyclopentyloxy-4-methoxy-phenyl)-hex...)Show SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CCN2[C@@H]1CCC2=O Show InChI InChI=1S/C19H25NO3/c1-22-17-8-6-13(12-18(17)23-14-4-2-3-5-14)15-10-11-20-16(15)7-9-19(20)21/h6,8,12,14-16H,2-5,7,9-11H2,1H3/t15-,16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 4B |
J Med Chem 38: 4848-54 (1996)
BindingDB Entry DOI: 10.7270/Q2DZ079X |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470740
(CHEMBL264851)Show InChI InChI=1S/C20H29NO4/c1-14(2)24-20(22)21-11-10-16(13-21)15-8-9-18(23-3)19(12-15)25-17-6-4-5-7-17/h8-9,12,14,16-17H,4-7,10-11,13H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470754
(CHEMBL288928)Show InChI InChI=1S/C23H27NO3/c1-26-21-12-11-18(15-22(21)27-20-9-5-6-10-20)19-13-14-24(16-19)23(25)17-7-3-2-4-8-17/h2-4,7-8,11-12,15,19-20H,5-6,9-10,13-14,16H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50029951
((7R,7aS)-7-(3-Cyclopentyloxy-4-methoxy-phenyl)-tet...)Show SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CCN2[C@@H]1COC2=O Show InChI InChI=1S/C18H23NO4/c1-21-16-7-6-12(10-17(16)23-13-4-2-3-5-13)14-8-9-19-15(14)11-22-18(19)20/h6-7,10,13-15H,2-5,8-9,11H2,1H3/t14-,15-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 4B |
J Med Chem 38: 4848-54 (1996)
BindingDB Entry DOI: 10.7270/Q2DZ079X |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470725
(CHEMBL36318)Show InChI InChI=1S/C21H25NO3S/c1-24-18-9-8-15(13-19(18)25-17-5-2-3-6-17)16-10-11-22(14-16)21(23)20-7-4-12-26-20/h4,7-9,12-13,16-17H,2-3,5-6,10-11,14H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470743
(CHEMBL422578)Show InChI InChI=1S/C19H27NO4/c1-3-23-19(21)20-11-10-15(13-20)14-8-9-17(22-2)18(12-14)24-16-6-4-5-7-16/h8-9,12,15-16H,3-7,10-11,13H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50285057
(CHEMBL61876 | tert-butyl 3-(3-cyclopentyloxy-4-met...)Show SMILES COC[C@@H]1CN(C[C@H]1c1ccc(OC)c(OC2CCCC2)c1)C(=O)OC(C)(C)C Show InChI InChI=1S/C23H35NO5/c1-23(2,3)29-22(25)24-13-17(15-26-4)19(14-24)16-10-11-20(27-5)21(12-16)28-18-8-6-7-9-18/h10-12,17-19H,6-9,13-15H2,1-5H3/t17-,19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50285041
(CHEMBL301053 | methyl 3-cyano-4-(3-cyclopentyloxy-...)Show SMILES COC(=O)N1C[C@@H](C#N)[C@@H](C1)c1ccc(OC)c(OC2CCCC2)c1 Show InChI InChI=1S/C19H24N2O4/c1-23-17-8-7-13(9-18(17)25-15-5-3-4-6-15)16-12-21(19(22)24-2)11-14(16)10-20/h7-9,14-16H,3-6,11-12H2,1-2H3/t14-,16+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470748
(CHEMBL36724 | TCMDC-131880)Show InChI InChI=1S/C17H22N2O2/c1-20-16-7-6-13(14-8-9-19(11-14)12-18)10-17(16)21-15-4-2-3-5-15/h6-7,10,14-15H,2-5,8-9,11H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 89 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470735
(CHEMBL287687)Show InChI InChI=1S/C18H25NO3/c1-13(20)19-10-9-15(12-19)14-7-8-17(21-2)18(11-14)22-16-5-3-4-6-16/h7-8,11,15-16H,3-6,9-10,12H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 89 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470739
(CHEMBL413274)Show InChI InChI=1S/C17H23NO3/c1-20-16-7-6-13(14-8-9-18(11-14)12-19)10-17(16)21-15-4-2-3-5-15/h6-7,10,12,14-15H,2-5,8-9,11H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 91 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470727
(CHEMBL2093097)Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CCN(C1)C(N)=O |r| Show InChI InChI=1S/C17H24N2O3/c1-21-15-7-6-12(13-8-9-19(11-13)17(18)20)10-16(15)22-14-4-2-3-5-14/h6-7,10,13-14H,2-5,8-9,11H2,1H3,(H2,18,20)/t13-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470755
(CHEMBL36626)Show InChI InChI=1S/C18H25NO4/c1-21-16-8-7-13(11-17(16)23-15-5-3-4-6-15)14-9-10-19(12-14)18(20)22-2/h7-8,11,14-15H,3-6,9-10,12H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470749
(CHEMBL34846)Show InChI InChI=1S/C19H28N2O3/c1-20(2)19(22)21-11-10-15(13-21)14-8-9-17(23-3)18(12-14)24-16-6-4-5-7-16/h8-9,12,15-16H,4-7,10-11,13H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 145 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50285049
((3S,4R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrr...)Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CN(C[C@H]1C(O)=O)C(=O)OC(C)(C)C Show InChI InChI=1S/C22H31NO6/c1-22(2,3)29-21(26)23-12-16(17(13-23)20(24)25)14-9-10-18(27-4)19(11-14)28-15-7-5-6-8-15/h9-11,15-17H,5-8,12-13H2,1-4H3,(H,24,25)/t16-,17+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470729
(CHEMBL284970)Show InChI InChI=1S/C17H24N2O2S/c1-20-15-7-6-12(13-8-9-19(11-13)17(18)22)10-16(15)21-14-4-2-3-5-14/h6-7,10,13-14H,2-5,8-9,11H2,1H3,(H2,18,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 155 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470730
(CHEMBL35213)Show SMILES COc1ccc(cc1OC1CCCC1)C1CCN(C1)C(=O)NCc1ccccc1 Show InChI InChI=1S/C24H30N2O3/c1-28-22-12-11-19(15-23(22)29-21-9-5-6-10-21)20-13-14-26(17-20)24(27)25-16-18-7-3-2-4-8-18/h2-4,7-8,11-12,15,20-21H,5-6,9-10,13-14,16-17H2,1H3,(H,25,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 158 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470751
(CHEMBL286391)Show InChI InChI=1S/C18H24N2O4/c1-23-15-7-6-12(10-16(15)24-14-4-2-3-5-14)13-8-9-20(11-13)18(22)17(19)21/h6-7,10,13-14H,2-5,8-9,11H2,1H3,(H2,19,21) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 158 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50048243
((3S,4R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrr...)Show SMILES COC(=O)[C@@H]1CN(C[C@H]1c1ccc(OC)c(OC2CCCC2)c1)C(=O)OC Show InChI InChI=1S/C20H27NO6/c1-24-17-9-8-13(10-18(17)27-14-6-4-5-7-14)15-11-21(20(23)26-3)12-16(15)19(22)25-2/h8-10,14-16H,4-7,11-12H2,1-3H3/t15-,16+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470738
(CHEMBL36728)Show InChI InChI=1S/C17H24N2O3/c1-21-15-7-6-12(13-8-9-19(11-13)17(18)20)10-16(15)22-14-4-2-3-5-14/h6-7,10,13-14H,2-5,8-9,11H2,1H3,(H2,18,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 182 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470737
(CHEMBL290191)Show SMILES COc1ccc(cc1OC1CCCC1)C1CCN(C1)C(=O)c1cc2ccccc2[nH]1 Show InChI InChI=1S/C25H28N2O3/c1-29-23-11-10-17(15-24(23)30-20-7-3-4-8-20)19-12-13-27(16-19)25(28)22-14-18-6-2-5-9-21(18)26-22/h2,5-6,9-11,14-15,19-20,26H,3-4,7-8,12-13,16H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 182 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470726
(CHEMBL1169563)Show SMILES COC(=O)N1CC[C@H](C1)c1ccc(OC)c(OC2CCCC2)c1 |r| Show InChI InChI=1S/C18H25NO4/c1-21-16-8-7-13(11-17(16)23-15-5-3-4-6-15)14-9-10-19(12-14)18(20)22-2/h7-8,11,14-15H,3-6,9-10,12H2,1-2H3/t14-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 186 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50285061
(CHEMBL61856 | tert-butyl 3-carbamoyl-4-(3-cyclopen...)Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CN(C[C@H]1C(N)=O)C(=O)OC(C)(C)C Show InChI InChI=1S/C22H32N2O5/c1-22(2,3)29-21(26)24-12-16(17(13-24)20(23)25)14-9-10-18(27-4)19(11-14)28-15-7-5-6-8-15/h9-11,15-17H,5-8,12-13H2,1-4H3,(H2,23,25)/t16-,17+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470747
(CHEMBL38219)Show InChI InChI=1S/C20H25NO3/c1-3-6-20(22)21-12-11-16(14-21)15-9-10-18(23-2)19(13-15)24-17-7-4-5-8-17/h9-10,13,16-17H,4-5,7-8,11-12,14H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 195 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
| 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
PubMed
| 221 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 4B |
J Med Chem 38: 4848-54 (1996)
BindingDB Entry DOI: 10.7270/Q2DZ079X |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| 224 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50285054
(1-(tert-butyl) 3-methyl 4-[4-methoxy-3-(3-phenoxyp...)Show SMILES COC(=O)[C@@H]1CN(C[C@H]1c1ccc(OC)c(OCCCOc2ccccc2)c1)C(=O)OC(C)(C)C Show InChI InChI=1S/C27H35NO7/c1-27(2,3)35-26(30)28-17-21(22(18-28)25(29)32-5)19-12-13-23(31-4)24(16-19)34-15-9-14-33-20-10-7-6-8-11-20/h6-8,10-13,16,21-22H,9,14-15,17-18H2,1-5H3/t21-,22+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470728
(CHEMBL285532)Show InChI InChI=1S/C20H29NO3/c1-3-6-20(22)21-12-11-16(14-21)15-9-10-18(23-2)19(13-15)24-17-7-4-5-8-17/h9-10,13,16-17H,3-8,11-12,14H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 269 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50029953
((7R,7aR)-7-(3-Cyclopentyloxy-4-methoxy-phenyl)-tet...)Show InChI InChI=1S/C18H23NO4/c1-21-16-7-6-12(10-17(16)23-13-4-2-3-5-13)14-8-9-19-15(14)11-22-18(19)20/h6-7,10,13-15H,2-5,8-9,11H2,1H3/t14-,15+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 282 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 4B |
J Med Chem 38: 4848-54 (1996)
BindingDB Entry DOI: 10.7270/Q2DZ079X |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470733
(CHEMBL290805)Show InChI InChI=1S/C17H25NO4S/c1-21-16-8-7-13(11-17(16)22-15-5-3-4-6-15)14-9-10-18(12-14)23(2,19)20/h7-8,11,14-15H,3-6,9-10,12H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 282 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50285063
((3S,4R)-3-tert-Butoxycarbonylamino-4-(3-cyclopenty...)Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CN(C[C@H]1NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1 Show InChI InChI=1S/C29H38N2O6/c1-29(2,3)37-27(32)30-24-18-31(28(33)35-19-20-10-6-5-7-11-20)17-23(24)21-14-15-25(34-4)26(16-21)36-22-12-8-9-13-22/h5-7,10-11,14-16,22-24H,8-9,12-13,17-19H2,1-4H3,(H,30,32)/t23-,24+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470734
(CHEMBL287226)Show InChI InChI=1S/C20H29NO3/c1-14(2)20(22)21-11-10-16(13-21)15-8-9-18(23-3)19(12-15)24-17-6-4-5-7-17/h8-9,12,14,16-17H,4-7,10-11,13H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50029957
((7R,7aS)-7-(3-Cyclopentyloxy-4-methoxy-phenyl)-hex...)Show InChI InChI=1S/C19H25NO3/c1-22-17-8-6-13(12-18(17)23-14-4-2-3-5-14)15-10-11-20-16(15)7-9-19(20)21/h6,8,12,14-16H,2-5,7,9-11H2,1H3/t15-,16+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 338 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 4B |
J Med Chem 38: 4848-54 (1996)
BindingDB Entry DOI: 10.7270/Q2DZ079X |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50285062
(CHEMBL59820 | methyl 3-(3-cyclopentyloxy-4-methoxy...)Show SMILES CCC(=O)[C@@H]1CN(C[C@H]1c1ccc(OC)c(OC2CCCC2)c1)C(=O)OC Show InChI InChI=1S/C21H29NO5/c1-4-18(23)17-13-22(21(24)26-3)12-16(17)14-9-10-19(25-2)20(11-14)27-15-7-5-6-8-15/h9-11,15-17H,4-8,12-13H2,1-3H3/t16-,17+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50285056
(CHEMBL61284 | methyl 1-amino(thioxo)methyl-4-(3-cy...)Show SMILES COC(=O)[C@@H]1CN(C[C@H]1c1ccc(OC)c(OC2CCCC2)c1)C(N)=S Show InChI InChI=1S/C19H26N2O4S/c1-23-16-8-7-12(9-17(16)25-13-5-3-4-6-13)14-10-21(19(20)26)11-15(14)18(22)24-2/h7-9,13-15H,3-6,10-11H2,1-2H3,(H2,20,26)/t14-,15+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) |
Bioorg Med Chem Lett 5: 1977-1982 (1995)
Article DOI: 10.1016/0960-894X(95)00336-R
BindingDB Entry DOI: 10.7270/Q2PN95MX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50470746
(CHEMBL37386)Show SMILES COc1ccc(cc1OC1CCCC1)C1CCN(C1)C(=O)Nc1ccccc1 Show InChI InChI=1S/C23H28N2O3/c1-27-21-12-11-17(15-22(21)28-20-9-5-6-10-20)18-13-14-25(16-18)23(26)24-19-7-3-2-4-8-19/h2-4,7-8,11-12,15,18,20H,5-6,9-10,13-14,16H2,1H3,(H,24,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 427 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cAMP hydrolysis by the human phosphodiesterase 4B enzyme |
J Med Chem 38: 1505-10 (1995)
Article DOI: 10.1021/jm00009a011
BindingDB Entry DOI: 10.7270/Q2833VRG |
More data for this
Ligand-Target Pair | |
Search and Browse
