| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cysteinyl leukotriene receptor 1 |
|---|
| Ligand | BDBM50296099 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_579418 (CHEMBL1053173) |
|---|
| IC50 | 4.8±n/a nM |
|---|
| Citation |  Bonjoch, J; Diaba, F; Pagès, L; Pérez, D; Soca, L; Miralpeix, M; Vilella, D; Anton, P; Puig, C Synthesis and structure-activity relationships of gamma-carboline derivatives as potent and selective cysLT(1) antagonists. Bioorg Med Chem Lett19:4299-302 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cysteinyl leukotriene receptor 1 |
|---|
| Name: | Cysteinyl leukotriene receptor 1 |
|---|
| Synonyms: | CLTR1_CAVPO | CYSLTR1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 39007.58 |
|---|
| Organism: | GUINEA PIG |
|---|
| Description: | Leukotriene D4 0 GUINEA PIG::Q2NNR5 |
|---|
| Residue: | 340 |
|---|
| Sequence: | MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSA
FQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAM
SFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPP
QDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIV
VTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFF
SGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
|
|
|
|---|
| BDBM50296099 |
|---|
| n/a |
|---|
| Name | BDBM50296099 |
|---|
| Synonyms: | 3-(9-(3-(2-(7-chloroquinolin-2-yl)vinyl)benzyl)-9H-carbazol-3-yl)propanoic acid | CHEMBL562930 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H25ClN2O2 |
|---|
| Mol. Mass. | 517.017 |
|---|
| SMILES | OC(=O)CCc1ccc2n(Cc3cccc(\C=C\c4ccc5ccc(Cl)cc5n4)c3)c3ccccc3c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
