| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP3 subtype |
|---|
| Ligand | BDBM50414549 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_581546 (CHEMBL1060745) |
|---|
| Ki | 6.31±n/a nM |
|---|
| Citation |  Hilfiker, MA; Wang, N; Hou, X; Du, Z; Pullen, MA; Nord, M; Nagilla, R; Fries, HE; Wu, CW; Sulpizio, AC; Jaworski, JP; Morrow, D; Edwards, RM; Jin, J Discovery of novel aminothiadiazole amides as selective EP(3) receptor antagonists. Bioorg Med Chem Lett19:4292-5 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin E2 receptor EP3 subtype |
|---|
| Name: | Prostaglandin E2 receptor EP3 subtype |
|---|
| Synonyms: | PE2R3_RAT | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor EP3 subtype | Prostanoid EP3 receptor | Ptger3 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 39958.37 |
|---|
| Organism: | RAT |
|---|
| Description: | Prostaglandin E2 PTGER2 RAT::P34980 |
|---|
| Residue: | 365 |
|---|
| Sequence: | MAGVWAPEHSVEAHSNQSSAADGCGSVSVAFPITMMVTGFVGNALAMLLVVRSYRRRESK
RKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLS
SLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWP
GTWCFISTGPAGNETDSAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKA
AASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKE
CNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSVLMWS
DQLER
|
|
|
|---|
| BDBM50414549 |
|---|
| n/a |
|---|
| Name | BDBM50414549 |
|---|
| Synonyms: | CHEMBL563480 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H16Cl2N4O2S |
|---|
| Mol. Mass. | 435.327 |
|---|
| SMILES | CCN1CCOc2ccc(cc12)C(=O)Nc1nnc(s1)-c1c(Cl)cccc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
