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TargetChemokine receptor type 1 (CXCR1)
LigandBDBM50200887
Substrate/Competitorn/a
Meas. Tech.ChEMBL_584048
Ki 210±n/a nM
Citation Aki CChao JFerreira JADwyer MPYu YChao JMerritt RJLai GWu MHipkin RWFan XGonsiorek WFosseta JRindgen DFine JLundell DTaveras AGBiju P Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region. Bioorg Med Chem Lett 19:4446-9 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Chemokine receptor type 1 (CXCR1)
Name:Interleukin-8 receptors, CXCR1/CXCR2
Synonyms:C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:Enzyme
Mol. Mass.:39803.83
Organism:Homo sapiens (Human)
Description:P25024
Residue:350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50200887
n/a
NameBDBM50200887
Synonyms:(R)-3-(3,4-dioxo-2-(1-(thiophen-2-yl)propylamino)cyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide | CHEMBL385715
TypeSmall organic molecule
Emp. Form.C20H21N3O4S
Mol. Mass.399.463
SMILESCC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cccs1 |r|
Structure
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