Reaction Details |
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Target | Hexokinase-4 |
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Ligand | BDBM50297768 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_584072 (CHEMBL1058313) |
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EC50 | 930±n/a nM |
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Citation | Ishikawa, M; Nonoshita, K; Ogino, Y; Nagae, Y; Tsukahara, D; Hosaka, H; Maruki, H; Ohyama, S; Yoshimoto, R; Sasaki, K; Nagata, Y; Eiki, J; Nishimura, T Discovery of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators. Bioorg Med Chem Lett19:4450-4 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hexokinase-4 |
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Name: | Hexokinase-4 |
Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
Type: | Enzyme |
Mol. Mass.: | 52175.81 |
Organism: | Homo sapiens (Human) |
Description: | P35557 |
Residue: | 465 |
Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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BDBM50297768 |
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n/a |
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Name | BDBM50297768 |
Synonyms: | 1-(2-(5-(3-fluorophenoxy)-2-(pyridin-2-yl)-1H-benzo[d]imidazol-6-yl)pyrrolidin-1-yl)ethanone | CHEMBL561283 |
Type | Small organic molecule |
Emp. Form. | C24H21FN4O2 |
Mol. Mass. | 416.4475 |
SMILES | CC(=O)N1CCCC1c1cc2nc([nH]c2cc1Oc1cccc(F)c1)-c1ccccn1 |
Structure |
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