| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50297779 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_584072 (CHEMBL1058313) |
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| EC50 | 2400±n/a nM |
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| Citation |  Ishikawa, M; Nonoshita, K; Ogino, Y; Nagae, Y; Tsukahara, D; Hosaka, H; Maruki, H; Ohyama, S; Yoshimoto, R; Sasaki, K; Nagata, Y; Eiki, J; Nishimura, T Discovery of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators. Bioorg Med Chem Lett19:4450-4 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52175.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35557 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM50297779 |
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| n/a |
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| Name | BDBM50297779 |
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| Synonyms: | 1-(2-(5-(3-methoxyphenoxy)-2-(pyridin-2-yl)-1H-benzo[d]imidazol-6-yl)pyrrolidin-1-yl)ethanone | CHEMBL564241 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24N4O3 |
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| Mol. Mass. | 428.4831 |
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| SMILES | COc1cccc(Oc2cc3[nH]c(nc3cc2C2CCCN2C(C)=O)-c2ccccn2)c1 |
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| Structure | 
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