Ki Summary

Reaction Details

Report a problem with these data

Target

Tryptophan 5-hydroxylase 1

Ligand

BDBM50243613

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_597945 (CHEMBL1042730)

IC50

24±n/a nM

Citation

Jin, H; Cianchetta, G; Devasagayaraj, A; Gu, K; Marinelli, B; Samala, L; Scott, S; Stouch, T; Tunoori, A; Wang, Y; Zang, Y; Zhang, C; David Kimball, S; Main, AJ; Ding, ZM; Sun, W; Yang, Q; Yu, XQ; Powell, DR; Wilson, A; Liu, Q; Shi, ZC Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors. Bioorg Med Chem Lett19:5229-32 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Tryptophan 5-hydroxylase 1

Name:

Tryptophan 5-hydroxylase 1

Synonyms:

Type:

PROTEIN

Mol. Mass.:

50990.64

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1361824

Residue:

444

Sequence:

MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI

BDBM50243613

n/a

Name

BDBM50243613

Synonyms:

(S)-2-Amino-3-(4-(4-amino-6-((naphthalene-2-ylmethyl)-amino)-(1,3,5)triazin-2-yl)-phenyl)-propionic acid | (S)-2-amino-3-(4-(4-amino-6-(naphthalen-2-ylmethylamino)-1,3,5-triazin-2-yl)phenyl)propanoic acid | CHEMBL460882

Type

Small organic molecule

Emp. Form.

C23H22N6O2

Mol. Mass.

414.4598

SMILES

N[C@@H](Cc1ccc(cc1)-c1nc(N)nc(NCc2ccc3ccccc3c2)n1)C(O)=O |r|

Structure