| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 3 |
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| Ligand | BDBM50301333 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_599488 (CHEMBL1049024) |
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| Ki | 23000±n/a nM |
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| Citation |  McGuinness, BF; Carroll, CD; Zawacki, LG; Dong, G; Yang, C; Hobbs, DW; Jacob-Samuel, B; Hall, JW; Jenh, CH; Kozlowski, JA; Anilkumar, GN; Rosenblum, SB Novel CXCR3 antagonists with a piperazinyl-piperidine core. Bioorg Med Chem Lett19:5205-8 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 3 |
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| Name: | C-X-C chemokine receptor type 3 |
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| Synonyms: | AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40665.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 368 |
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| Sequence: | MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALY
SLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFG
SGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCL
LFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILA
VLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAK
SVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSET
SEASYSGL
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| BDBM50301333 |
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| n/a |
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| Name | BDBM50301333 |
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| Synonyms: | 5-chloro-6-((2-((1-(4-chlorobenzyl)piperidin-4-yl)(methyl)amino)ethyl)(methyl)amino)-N-(3,4-dichlorobenzyl)nicotinamide | CHEMBL571815 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H33Cl4N5O |
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| Mol. Mass. | 609.417 |
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| SMILES | CN(CCN(C)c1ncc(cc1Cl)C(=O)NCc1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccc(Cl)cc2)CC1 |
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| Structure | 
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