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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase B-raf | ||
| Ligand | BDBM50303114 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_597720 (CHEMBL1043507) | ||
| IC50 | 6.7±n/a nM | ||
| Citation |  Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Novel pyrazolopyrimidines as highly potent B-Raf inhibitors. Bioorg Med Chem Lett19:6957-61 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase B-raf | |||
| Name: | Serine/threonine-protein kinase B-raf | ||
| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 84446.00 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P15056 | ||
| Residue: | 766 | ||
| Sequence: |
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| BDBM50303114 | |||
| n/a | |||
| Name | BDBM50303114 | ||
| Synonyms: | 3-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-N-ethyl-8-azabicyclo[3.2.1]octane-8-carboxamide | CHEMBL570658 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H28N8O | ||
| Mol. Mass. | 492.5749 | ||
| SMILES | CCNC(=O)N1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 |THB:13:11:5:7.8,(29.22,-.78,;27.9,-1.58,;26.56,-.83,;25.24,-1.63,;23.89,-.88,;25.27,-3.16,;24.73,-4.63,;23.21,-5.31,;24.58,-5.28,;25.77,-4.41,;27.31,-5.26,;26.77,-6.73,;26.33,-5.54,;26.78,-8.27,;25.45,-9.04,;25.45,-10.58,;26.78,-11.35,;28.11,-10.58,;29.59,-11.06,;30.5,-9.81,;29.58,-8.55,;28.11,-9.03,;32.03,-9.8,;32.8,-11.14,;34.34,-11.14,;35.11,-9.81,;34.33,-8.47,;32.79,-8.48,;29.65,-12.6,;28.35,-13.42,;28.41,-14.96,;29.77,-15.68,;31.08,-14.85,;32.58,-15.27,;33.43,-13.97,;32.47,-12.76,;31.01,-13.31,)| | ||
| Structure | 
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