Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Serine/threonine-protein kinase B-raf | ||
Ligand | BDBM50303118 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_597720 (CHEMBL1043507) | ||
IC50 | 46.6±n/a nM | ||
Citation | Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Novel pyrazolopyrimidines as highly potent B-Raf inhibitors. Bioorg Med Chem Lett19:6957-61 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase B-raf | |||
Name: | Serine/threonine-protein kinase B-raf | ||
Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 84446.00 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P15056 | ||
Residue: | 766 | ||
Sequence: |
| ||
BDBM50303118 | |||
n/a | |||
Name | BDBM50303118 | ||
Synonyms: | 7-(8-ethyl-8-azabicyclo[3.2.1]octan-3-yl)-3-(1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine | CHEMBL570422 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H27N7 | ||
Mol. Mass. | 449.5502 | ||
SMILES | CCN1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 |THB:10:8:2:4.5,(30.67,-24,;29.35,-24.8,;29.38,-26.34,;28.85,-27.8,;27.32,-28.48,;28.7,-28.45,;29.89,-27.59,;31.43,-28.43,;30.88,-29.9,;30.44,-28.71,;30.89,-31.44,;29.56,-32.21,;29.56,-33.76,;30.89,-34.53,;32.22,-33.76,;33.7,-34.23,;34.61,-32.98,;33.7,-31.73,;32.22,-32.21,;36.14,-32.98,;36.91,-34.31,;38.45,-34.31,;39.22,-32.98,;38.44,-31.64,;36.9,-31.65,;33.76,-35.77,;32.47,-36.59,;32.52,-38.13,;33.89,-38.85,;35.2,-38.03,;36.69,-38.44,;37.54,-37.15,;36.58,-35.93,;35.13,-36.48,)| | ||
Structure |