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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase B-raf | ||
| Ligand | BDBM50303120 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_597720 (CHEMBL1043507) | ||
| IC50 | 75.90±n/a nM | ||
| Citation |  Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Novel pyrazolopyrimidines as highly potent B-Raf inhibitors. Bioorg Med Chem Lett19:6957-61 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase B-raf | |||
| Name: | Serine/threonine-protein kinase B-raf | ||
| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 84446.00 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P15056 | ||
| Residue: | 766 | ||
| Sequence: |
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| BDBM50303120 | |||
| n/a | |||
| Name | BDBM50303120 | ||
| Synonyms: | 1-(3-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octan-8-yl)propan-2-one | CHEMBL571971 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H27N7O | ||
| Mol. Mass. | 477.5603 | ||
| SMILES | CC(=O)CN1C2CCC1CC(C2)c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 |THB:12:10:4:6.7,(13.66,1.58,;12.31,2.32,;12.28,3.86,;10.99,1.53,;11.02,-.01,;10.48,-1.47,;8.96,-2.16,;10.33,-2.12,;11.53,-1.26,;13.07,-2.1,;12.52,-3.58,;12.08,-2.39,;12.53,-5.11,;11.2,-5.88,;11.2,-7.43,;12.53,-8.2,;13.86,-7.43,;15.34,-7.9,;16.25,-6.65,;15.34,-5.4,;13.86,-5.88,;17.78,-6.65,;18.55,-7.98,;20.09,-7.98,;20.86,-6.65,;20.08,-5.31,;18.54,-5.32,;15.4,-9.44,;14.1,-10.26,;14.16,-11.8,;15.53,-12.52,;16.83,-11.7,;18.33,-12.11,;19.18,-10.82,;18.22,-9.61,;16.77,-10.15,)| | ||
| Structure | 
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