Ki Summary

Reaction Details

Report a problem with these data

Target

Serine/threonine-protein kinase B-raf

Ligand

BDBM50303124

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_597720 (CHEMBL1043507)

IC50

3.8±n/a nM

Citation

Di Grandi, MJ; Berger, DM; Hopper, DW; Zhang, C; Dutia, M; Dunnick, AL; Torres, N; Levin, JI; Diamantidis, G; Zapf, CW; Bloom, JD; Hu, Y; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Novel pyrazolopyrimidines as highly potent B-Raf inhibitors. Bioorg Med Chem Lett19:6957-61 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase B-raf

Name:

Serine/threonine-protein kinase B-raf

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

84446.00

Organism:

Homo sapiens (Human)

Description:

P15056

Residue:

766

Sequence:

MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH

BDBM50303124

n/a

Name

BDBM50303124

Synonyms:

7-(8-azabicyclo[3.2.1]octan-3-yl)-3-(7-fluoro-1H-indazol-4-yl)-2-(pyridin-4-yl)-1,2-dihydropyrazolo[1,5-a]pyrimidine | CHEMBL584527

Type

Small organic molecule

Emp. Form.

C25H22FN7

Mol. Mass.

439.4875

SMILES

Fc1ccc(-c2c(nn3c(ccnc23)C2CC3CCC(C2)N3)-c2ccncc2)c2cn[nH]c12 |TLB:9:14:21:17.18,(31.91,-31.64,;31.85,-30.1,;30.48,-29.38,;30.43,-27.84,;31.72,-27.02,;31.66,-25.48,;32.57,-24.24,;31.66,-22.98,;30.18,-23.46,;28.85,-22.7,;27.52,-23.47,;27.52,-25.01,;28.85,-25.78,;30.18,-25.01,;28.84,-21.16,;28.4,-19.97,;26.81,-19.06,;25.29,-19.74,;26.66,-19.7,;27.85,-18.84,;29.39,-19.69,;27.34,-17.59,;34.1,-24.23,;34.87,-25.57,;36.41,-25.57,;37.18,-24.23,;36.4,-22.9,;34.86,-22.9,;33.09,-27.73,;34.54,-27.19,;35.5,-28.4,;34.65,-29.69,;33.16,-29.28,)|

Structure