| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM50304247 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_605400 (CHEMBL1073394) |
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| IC50 | 47±n/a nM |
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| Citation |  Sheng, R; Lin, X; Zhang, J; Chol, KS; Huang, W; Yang, B; He, Q; Hu, Y Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors. Bioorg Med Chem17:6692-8 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | ACES_RAT | Acetylcholinesterase (AChE) | Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) | Acetylcholinesterase precursor | Acetylcholinesterase, AChE | Ache |
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| Type: | Enzyme |
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| Mol. Mass.: | 68193.62 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P37136 |
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| Residue: | 614 |
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| Sequence: | MRPPWYPLHTPSLASPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPV
SAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSM
NYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASV
GMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTEL
ISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPDALINTGDFQDLQVLVG
VVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPE
DPAHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGY
EIEFIFGLPLDPSLNYTVEERIFAQRLMQYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQ
YVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQERCSDL
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| BDBM50304247 |
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| n/a |
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| Name | BDBM50304247 |
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| Synonyms: | (E)-1-(2-Hydroxy-4,5-dimethoxyphenyl)-3-[3-(pyrrolidin-1-ylmethyl)-phenyl]-prop-2-en-1-one | CHEMBL594225 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23NO4 |
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| Mol. Mass. | 353.4116 |
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| SMILES | COc1cc(O)c(cc1OC)C(=O)\C=C\c1cccc(c1)N1CCCC1 |
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| Structure | 
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