Ki Summary

Reaction Details

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Target

Oxysterols receptor LXR-beta

Ligand

BDBM50306082

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_605983 (CHEMBL1069927)

IC50

44±n/a nM

Citation

Travins, JM; Bernotas, RC; Kaufman, DH; Quinet, E; Nambi, P; Feingold, I; Huselton, C; Wilhelmsson, A; Goos-Nilsson, A; Wrobel, J 1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists. Bioorg Med Chem Lett20:526-30 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Oxysterols receptor LXR-beta

Name:

Oxysterols receptor LXR-beta

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

50978.79

Organism:

Homo sapiens (Human)

Description:

P55055

Residue:

460

Sequence:

MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE

BDBM50306082

n/a

Name

BDBM50306082

Synonyms:

4-chloro-1-(2-chloro-5-(3-fluoro-5-(methylsulfonyl)phenoxy)phenyl)-2-methyl-1H-benzo[d]imidazole | CHEMBL595455

Type

Small organic molecule

Emp. Form.

C21H15Cl2FN2O3S

Mol. Mass.

465.325

SMILES

Cc1nc2c(Cl)cccc2n1-c1cc(Oc2cc(F)cc(c2)S(C)(=O)=O)ccc1Cl |(24.36,-49.54,;22.82,-49.54,;21.92,-50.79,;20.45,-50.31,;19.12,-51.09,;19.12,-52.63,;17.79,-50.32,;17.79,-48.78,;19.12,-48.01,;20.45,-48.77,;21.92,-48.29,;21.9,-46.75,;23.24,-45.97,;23.22,-44.42,;24.55,-43.64,;25.89,-44.4,;25.9,-45.93,;27.23,-46.69,;27.25,-48.23,;28.56,-45.91,;28.54,-44.36,;27.2,-43.61,;29.86,-43.58,;31.19,-44.35,;30.95,-42.48,;28.76,-42.48,;21.88,-43.66,;20.54,-44.46,;20.56,-46,;19.24,-46.78,)|

Structure