Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Oxysterols receptor LXR-alpha | ||
| Ligand | BDBM50306083 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_605982 (CHEMBL1069926) | ||
| IC50 | 17±n/a nM | ||
| Citation |  Travins, JM; Bernotas, RC; Kaufman, DH; Quinet, E; Nambi, P; Feingold, I; Huselton, C; Wilhelmsson, A; Goos-Nilsson, A; Wrobel, J 1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists. Bioorg Med Chem Lett20:526-30 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Oxysterols receptor LXR-alpha | |||
| Name: | Oxysterols receptor LXR-alpha | ||
| Synonyms: | LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 50403.85 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13133 | ||
| Residue: | 447 | ||
| Sequence: |
| ||
| BDBM50306083 | |||
| n/a | |||
| Name | BDBM50306083 | ||
| Synonyms: | 4-chloro-1-(2-chloro-5-(3-(trifluoromethylsulfonyl)phenoxy)phenyl)-2-methyl-1H-benzo[d]imidazole | CHEMBL605723 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H13Cl2F3N2O3S | ||
| Mol. Mass. | 501.306 | ||
| SMILES | Cc1nc2c(Cl)cccc2n1-c1cc(Oc2cccc(c2)S(=O)(=O)C(F)(F)F)ccc1Cl |(40.06,-46.33,;38.52,-46.33,;37.61,-47.58,;36.15,-47.1,;34.82,-47.88,;34.82,-49.42,;33.48,-47.11,;33.49,-45.57,;34.81,-44.8,;36.15,-45.56,;37.61,-45.09,;37.6,-43.54,;38.93,-42.76,;38.92,-41.22,;40.25,-40.44,;41.58,-41.2,;41.59,-42.73,;42.93,-43.49,;44.26,-42.71,;44.24,-41.16,;42.9,-40.41,;45.56,-40.37,;46.64,-39.28,;44.46,-39.28,;46.88,-41.14,;48.22,-40.38,;46.88,-42.68,;48.37,-41.54,;37.57,-40.46,;36.24,-41.25,;36.26,-42.79,;34.94,-43.58,)| | ||
| Structure | 
| ||