Reaction Details |
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Target | RAC-gamma serine/threonine-protein kinase |
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Ligand | BDBM50306162 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_606084 (CHEMBL1072612) |
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IC50 | 500±n/a nM |
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Citation | Lin, H; Yamashita, DS; Xie, R; Zeng, J; Wang, W; Leber, J; Safonov, IG; Verma, S; Li, M; Lafrance, L; Venslavsky, J; Takata, D; Luengo, JI; Kahana, JA; Zhang, S; Robell, KA; Levy, D; Kumar, R; Choudhry, AE; Schaber, M; Lai, Z; Brown, BS; Donovan, BT; Minthorn, EA; Brown, KK; Heerding, DA Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridines. Bioorg Med Chem Lett20:684-8 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RAC-gamma serine/threonine-protein kinase |
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Name: | RAC-gamma serine/threonine-protein kinase |
Synonyms: | AKT3 | AKT3_HUMAN | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B (Akt 3) | Protein kinase B, gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT3 |
Type: | Enzyme |
Mol. Mass.: | 55769.36 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 479 |
Sequence: | MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
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BDBM50306162 |
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n/a |
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Name | BDBM50306162 |
Synonyms: | (S)-3-(2-amino-3-phenylpropoxy)-N-ethyl-6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-b]pyrazin-5-yl)pyridin-2-amine | CHEMBL593573 |
Type | Small organic molecule |
Emp. Form. | C26H27N7O2 |
Mol. Mass. | 469.5383 |
SMILES | CCNc1nc(-c2ccoc2)c(cc1OC[C@@H](N)Cc1ccccc1)-c1cnc2[nH]nc(C)c2n1 |r| |
Structure |
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