| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosinase |
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| Ligand | BDBM50240041 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_609027 (CHEMBL1064494) |
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| IC50 | 1800±n/a nM |
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| Citation |  Thanigaimalai, P; Lee, KC; Bang, SC; Lee, JH; Yun, CY; Roh, E; Hwang, BY; Kim, Y; Jung, SH Evaluation of 3,4-dihydroquinazoline-2(1H)-thiones as inhibitors of alpha-MSH-induced melanin production in melanoma B16 cells. Bioorg Med Chem18:1555-62 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosinase |
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| Name: | Tyrosinase |
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| Synonyms: | LB24-AB | Monophenol monooxygenase | SK29-AB | TYR | TYRO_HUMAN | Tumor rejection antigen AB |
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| Type: | Protein |
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| Mol. Mass.: | 60388.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14679 |
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| Residue: | 529 |
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| Sequence: | MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILL
SNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVR
RNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMH
YYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRD
AEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRN
PGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQS
SMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGH
NRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLG
AAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL
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| BDBM50240041 |
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| n/a |
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| Name | BDBM50240041 |
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| Synonyms: | 1-phenyl-2-thiourea | 1-phenylthiourea | CHEMBL263376 | N-Phenyl-thiourea | N-Phenylthiourea | phenylthiourea |
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| Type | Small organic molecule |
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| Emp. Form. | C7H8N2S |
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| Mol. Mass. | 152.217 |
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| SMILES | NC(=S)Nc1ccccc1 |
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| Structure | 
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