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TargetNAD(P)H dehydrogenase [quinone] 1
LigandBDBM50309777
Substrate/Competitorn/a
Meas. Tech.ChEMBL_610871
IC50 94±n/a nM
Citation Nolan KAHumphries MPBarnes JDoncaster JRCaraher MCTirelli NBryce RAWhitehead RCStratford IJ Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2. Bioorg Med Chem 18:696-706 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
NAD(P)H dehydrogenase [quinone] 1
Name:NAD(P)H dehydrogenase [quinone] 1
Synonyms:Azoreductase | DT-diaphorase | Menadione reductase | NAD(P)H:quinone oxidoreductase 1 | NQO1 | Phylloquinone reductase | QR1 | Quinone Reductase 1 | Quinone reductase 1)
Type:Homodimer
Mol. Mass.:30874.82
Organism:Homo sapiens (Human)
Description:n/a
Residue:274
Sequence:
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL
KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV
FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC
GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK
KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
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  Blast E-value cutoff:
BDBM50309777
n/a
NameBDBM50309777
Synonyms:5-(2-(dimethylamino)ethylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one N-oxide | CHEMBL597442
TypeSmall organic molecule
Emp. Form.C17H17N5O2
Mol. Mass.323.3492
SMILESC[N+](C)([O-])CCNc1ccc2nnn3c2c1c(=O)c1ccccc31
Structure
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