Reaction Details |
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Target | Histamine H3 receptor |
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Ligand | BDBM50309852 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_611486 (CHEMBL1069468) |
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Ki | 150±n/a nM |
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Citation | Cole, DC; Gross, JL; Comery, TA; Aschmies, S; Hirst, WD; Kelley, C; Kim, JI; Kubek, K; Ning, X; Platt, BJ; Robichaud, AJ; Solvibile, WR; Stock, JR; Tawa, G; Williams, MJ; Ellingboe, JW Benzimidazole- and indole-substituted 1,3'-bipyrrolidine benzamides as histamine H3 receptor antagonists. Bioorg Med Chem Lett20:1237-40 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H3 receptor |
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Name: | Histamine H3 receptor |
Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 48691.47 |
Organism: | Homo sapiens (Human) |
Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
Residue: | 445 |
Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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BDBM50309852 |
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n/a |
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Name | BDBM50309852 |
Synonyms: | (S)-1,3'-bipyrrolidin-1'-yl(4-((6-chloro-1H-indol-1-yl)methyl)phenyl)methanone | CHEMBL590625 |
Type | Small organic molecule |
Emp. Form. | C24H26ClN3O |
Mol. Mass. | 407.936 |
SMILES | Clc1ccc2ccn(Cc3ccc(cc3)C(=O)N3CC[C@@H](C3)N3CCCC3)c2c1 |r| |
Structure |
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