| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50311807 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_619906 (CHEMBL1110296) |
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| IC50 | 0.92±n/a nM |
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| Citation |  Remen, L; Bezençon, O; Richard-Bildstein, S; Bur, D; Prade, L; Corminboeuf, O; Boss, C; Grisostomi, C; Sifferlen, T; Strickner, P; Hess, P; Delahaye, S; Treiber, A; Weller, T; Binkert, C; Steiner, B; Fischli, W New classes of potent and bioavailable human renin inhibitors. Bioorg Med Chem Lett19:6762-5 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50311807 |
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| n/a |
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| Name | BDBM50311807 |
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| Synonyms: | (1R,5R)-3-(4-(3-(2-chloro-3,6-difluorophenoxy)propyl)phenyl)-N-cyclopropyl-N-(3-methoxy-2-methylbenzyl)-9-azabicyclo[3.3.1]non-2-ene-2-carboxamide | CHEMBL1076454 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H39ClF2N2O3 |
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| Mol. Mass. | 621.156 |
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| SMILES | COc1cccc(CN(C2CC2)C(=O)C2=C(C[C@H]3CCC[C@H]2N3)c2ccc(CCCOc3c(F)ccc(F)c3Cl)cc2)c1C |r,t:15| |
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| Structure | 
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