| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 6 |
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| Ligand | BDBM50312057 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_620622 (CHEMBL1114830) |
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| IC50 | >2000±n/a nM |
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| Citation |  Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg Med Chem Lett19:6519-23 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 6 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 6 |
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| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 6 | MAP kinase kinase 6 | MAP2K6 | MAPK/ERK kinase 6 | MAPKK 6 | MEK6 | MKK6 | MP2K6_HUMAN | Mitogen-activated protein kinase kinase 6 (MKK6) | PRKMK6 | SAPKK3 | SKK3 |
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| Type: | Protein |
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| Mol. Mass.: | 37494.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P52564 |
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| Residue: | 334 |
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| Sequence: | MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG
RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF
REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV
KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI
WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK
ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
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| BDBM50312057 |
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| n/a |
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| Name | BDBM50312057 |
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| Synonyms: | CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide | N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C29H24F3N5O |
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| Mol. Mass. | 515.529 |
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| SMILES | CN(C)Cc1ccc(cc1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 |
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| Structure | 
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