| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50312385 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_620646 (CHEMBL1114854) |
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| EC50 | >10000±n/a nM |
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| Citation |  Epple, R; Cow, C; Xie, Y; Azimioara, M; Russo, R; Wang, X; Wityak, J; Karanewsky, DS; Tuntland, T; Nguyêñ-Trân, VT; Cuc Ngo, C; Huang, D; Saez, E; Spalding, T; Gerken, A; Iskandar, M; Seidel, HM; Tian, SS Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists. J Med Chem53:77-105 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50312385 |
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| n/a |
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| Name | BDBM50312385 |
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| Synonyms: | 2-(4-((4,5-di(biphenyl-4-yl)thiazol-2-yl)methoxy)-2-methylphenoxy)acetic acid | CHEMBL1075893 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H29NO4S |
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| Mol. Mass. | 583.695 |
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| SMILES | Cc1cc(OCc2nc(c(s2)-c2ccc(cc2)-c2ccccc2)-c2ccc(cc2)-c2ccccc2)ccc1OCC(O)=O |
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| Structure | 
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