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TargetPeroxisome proliferator-activated receptor alpha (PPAR alpha)
LigandBDBM50312465
Substrate/Competitorn/a
Meas. Tech.ChEMBL_620646
EC50>10000±n/a nM
Citation Epple RCow CXie YAzimioara MRusso RWang XWityak JKaranewsky DSTuntland TNguyêñ-Trân VTCuc Ngo CHuang DSaez ESpalding TGerken AIskandar MSeidel HMTian SS Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists. J Med Chem 53:77-105 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Name:Peroxisome proliferator-activated receptor
Synonyms:Nuclear receptor subfamily 1 group C member 1 | PPAR alpha/gamma | PPAR-alpha | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor
Type:Enzyme
Mol. Mass.:52222.08
Organism:Homo sapiens (Human)
Description:Q07869
Residue:468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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  Blast E-value cutoff:
BDBM50312465
n/a
NameBDBM50312465
Synonyms:2-(3-(4-(2-(3,5-dichlorophenoxy)ethylcarbamoyl)-5-phenylisoxazol-3-yl)phenyl)acetic acid | CHEMBL1075665
TypeSmall organic molecule
Emp. Form.C26H20Cl2N2O5
Mol. Mass.511.353
SMILESOC(=O)Cc1cccc(c1)-c1noc(c1C(=O)NCCOc1cc(Cl)cc(Cl)c1)-c1ccccc1
Structure
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