| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor delta |
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| Ligand | BDBM50312425 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_620660 (CHEMBL1115681) |
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| EC50 | 31±n/a nM |
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| Citation |  Epple, R; Cow, C; Xie, Y; Azimioara, M; Russo, R; Wang, X; Wityak, J; Karanewsky, DS; Tuntland, T; Nguyêñ-Trân, VT; Cuc Ngo, C; Huang, D; Saez, E; Spalding, T; Gerken, A; Iskandar, M; Seidel, HM; Tian, SS Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists. J Med Chem53:77-105 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor delta |
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| Name: | Peroxisome proliferator-activated receptor delta |
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| Synonyms: | NUC1 | Nr1c2 | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR-beta | PPAR-delta | PPARD_MOUSE | Pparb | Ppard |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49719.14 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1288931 |
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| Residue: | 440 |
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| Sequence: | MEQPQEETPEAREEEKEEVAMGDGAPELNGGPEHTLPSSSCADLSQNSSPSSLLDQLQMG
CDGASGGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCDRICKIQKKN
RNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTASEGCQHNPQLADLKAFSKH
IYNAYLKNFNMTKKKARSILTGKSSHNAPFVIHDIETLWQAEKGLVWKQLVNGLPPYNEI
SVHVFYRCQSTTVETVRELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKD
GLLVANGSGFVTHEFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDR
PGLMNVPQVEAIQDTILRALEFHLQVNHPDSQYLFPKLLQKMADLRQLVTEHAQMMQWLK
KTESETLLHPLLQEIYKDMY
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| BDBM50312425 |
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| n/a |
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| Name | BDBM50312425 |
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| Synonyms: | 2-(4-((4-(4-(Cyclopentyloxy)phenyl)-5-(4-(trifluoromethoxy)-phenyl)thiazol-2-yl)methoxy)-2-methylphenoxy)acetic Acid | CHEMBL1075682 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H28F3NO6S |
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| Mol. Mass. | 599.617 |
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| SMILES | Cc1cc(OCc2nc(c(s2)-c2ccc(OC(F)(F)F)cc2)-c2ccc(OC3CCCC3)cc2)ccc1OCC(O)=O |
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| Structure | 
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