Reaction Details |
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Target | Cyclin-dependent kinase 2 |
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Ligand | BDBM50312944 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_615909 (CHEMBL1102923) |
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IC50 | >2000±n/a nM |
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Citation | Zeng, Q; Allen, JG; Bourbeau, MP; Wang, X; Yao, G; Tadesse, S; Rider, JT; Yuan, CC; Hong, FT; Lee, MR; Zhang, S; Lofgren, JA; Freeman, DJ; Yang, S; Li, C; Tominey, E; Huang, X; Hoffman, D; Yamane, HK; Fotsch, C; Dominguez, C; Hungate, R; Zhang, X Azole-based inhibitors of AKT/PKB for the treatment of cancer. Bioorg Med Chem Lett20:1559-64 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 2 |
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Name: | Cyclin-dependent kinase 2 |
Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 33938.17 |
Organism: | Homo sapiens (Human) |
Description: | P24941 |
Residue: | 298 |
Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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BDBM50312944 |
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n/a |
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Name | BDBM50312944 |
Synonyms: | (S)-N1-(5-(cinnolin-6-yl)thiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine | CHEMBL1081974 |
Type | Small organic molecule |
Emp. Form. | C21H18F3N5S |
Mol. Mass. | 429.461 |
SMILES | N[C@H](CNc1ncc(s1)-c1ccc2nnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| |
Structure |
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