| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50313621 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_614439 (CHEMBL1110509) |
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| IC50 | 0.08±n/a nM |
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| Citation |  Morriello, GJ; Mills, SG; Johnson, T; Reibarkh, M; Chicchi, G; DeMartino, J; Kurtz, M; Davies, P; Tsao, KL; Zheng, S; Tong, X; Carlson, E; Townson, K; Tattersall, FD; Wheeldon, A; Boyce, S; Collinson, N; Rupniak, N; Moore, S; DeVita, RJ Substituted fused bicyclic pyrrolizinones as potent, orally bioavailable hNK1 antagonists. Bioorg Med Chem Lett20:2007-12 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50313621 |
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| n/a |
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| Name | BDBM50313621 |
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| Synonyms: | (6R,7S,7aR)-1-amino-6-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-7-(4-fluorophenyl)-1-methyltetrahydro-1H-pyrrolizin-3(2H)-one | CHEMBL1093751 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23F7N2O2 |
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| Mol. Mass. | 504.4404 |
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| SMILES | C[C@@H](O[C@H]1CN2[C@H]([C@@H]1c1ccc(F)cc1)C(C)(N)CC2=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |r| |
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| Structure | 
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