Reaction Details |
| Report a problem with these data |
Target | Cysteine protease |
---|
Ligand | BDBM50314127 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_623874 (CHEMBL1105397) |
---|
Ki | 1400±n/a nM |
---|
Citation | Breuning, A; Degel, B; Schulz, F; Büchold, C; Stempka, M; Machon, U; Heppner, S; Gelhaus, C; Leippe, M; Leyh, M; Kisker, C; Rath, J; Stich, A; Gut, J; Rosenthal, PJ; Schmuck, C; Schirmeister, T Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids. J Med Chem53:1951-63 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cysteine protease |
---|
Name: | Cysteine protease |
Synonyms: | Rhodesain |
Type: | PROTEIN |
Mol. Mass.: | 48425.78 |
Organism: | Trypanosoma brucei rhodesiense |
Description: | ChEMBL_619861 |
Residue: | 450 |
Sequence: | MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAF
RFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEFRARYRNGASYFAAAQKRLRKTVN
VTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVS
CDTIDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDH
VDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDSSNP
PYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTPPPPPPPPPSATFTQDF
CEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGLSVPITVPL
DKCIPILIGSVEYHCSTNPPTKAARLVPHQ
|
|
|
BDBM50314127 |
---|
n/a |
---|
Name | BDBM50314127 |
Synonyms: | (S)-Benzyl-2-{(Z)-3-[(S)-1-((S)-1-benzyloxycarbonylethylcarbamoyl)-2-phenylethylcarbamoyl]acryloylamino}-3-phenylpropionate | CHEMBL1090971 |
Type | Small organic molecule |
Emp. Form. | C32H33N3O7 |
Mol. Mass. | 571.6203 |
SMILES | C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)\C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1)C(O)=O |r| |
Structure |
|