Reaction Details |
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Target | Beta-secretase 2 |
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Ligand | BDBM50314603 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_625147 (CHEMBL1115168) |
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IC50 | 1000±n/a nM |
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Citation | Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ Pyridinyl aminohydantoins as small molecule BACE1 inhibitors. Bioorg Med Chem Lett20:2326-9 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-secretase 2 |
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Name: | Beta-secretase 2 |
Synonyms: | AEPLC | ALP56 | ASP1 | ASP21 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | BACE2 | BACE2_HUMAN | Beta secretase 2 | Beta-secretase (BACE) | Beta-secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2) |
Type: | Protein |
Mol. Mass.: | 56171.20 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y5Z0 |
Residue: | 518 |
Sequence: | MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI
YLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD
RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG
AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
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BDBM50314603 |
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n/a |
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Name | BDBM50314603 |
Synonyms: | 2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one | CHEMBL1090027 |
Type | Small organic molecule |
Emp. Form. | C20H16FN5O |
Mol. Mass. | 361.3723 |
SMILES | CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cccnc1F |c:3| |
Structure |
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