Reaction Details |
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Target | Solute carrier family 12 member 5 |
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Ligand | BDBM50315373 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_625987 (CHEMBL1103506) |
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IC50 | 400±n/a nM |
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Citation | Pégurier, C; Bosman, N; Collart, P; Delporte, ML; Leclercq, K; Lengelé, S; Kanduluru, AK; Meunier, S; Pacico, N; Vadali, LR; Wagner, A; Wolff, C; Provins, L Benzyl prolinate derivatives as novel selective KCC2 blockers. Bioorg Med Chem Lett20:2542-5 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Solute carrier family 12 member 5 |
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Name: | Solute carrier family 12 member 5 |
Synonyms: | Kcc2 | S12A5_RAT | Slc12a5 |
Type: | PROTEIN |
Mol. Mass.: | 126249.28 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_818163 |
Residue: | 1139 |
Sequence: | MSRRFTVTSLPPAASAASADPESRRHSVADPRRLPREDVKGDGNPKESSPFINSTDTEKG
REYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSKEHEEAENNEGGKKKPVQAPRM
GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG
VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE
DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKS
AFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRLLNATCDEYFTR
NNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSVGLADGTPVDMDHPYVFSDMT
SYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACI
EGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDG
IVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACA
VQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA
EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQ
LKAGKGLTIVGSVLEGTFLDNHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHL
IQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGN
PERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTT
FLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDES
RGSIRRKNPANTRLRLNVPEETACDNEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEG
ETDPEKVHLTWTKDKSAAQKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLN
EVIVNKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS
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BDBM50315373 |
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n/a |
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Name | BDBM50315373 |
Synonyms: | 2-benzyl 1-methyl 2-benzylpyrrolidine-1,2-dicarboxylate | CHEMBL1088918 |
Type | Small organic molecule |
Emp. Form. | C21H23NO4 |
Mol. Mass. | 353.4116 |
SMILES | COC(=O)N1CCCC1(Cc1ccccc1)C(=O)OCc1ccccc1 |
Structure |
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