| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
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| Ligand | BDBM50319118 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_635633 (CHEMBL1119525) |
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| EC50 | 22±n/a nM |
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| Citation |  Schmidt, D; Smenton, A; Raghavan, S; Shen, H; Ding, FX; Carballo-Jane, E; Luell, S; Ciecko, T; Holt, TG; Wolff, M; Taggart, A; Wilsie, L; Krsmanovic, M; Ren, N; Blom, D; Cheng, K; McCann, PE; Waters, MG; Tata, J; Colletti, S Anthranilic acid replacements in a niacin receptor agonist. Bioorg Med Chem Lett20:3426-30 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 2 |
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| Name: | Hydroxycarboxylic acid receptor 2 |
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| Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 41868.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
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| Residue: | 363 |
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| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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| BDBM50319118 |
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| n/a |
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| Name | BDBM50319118 |
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| Synonyms: | 5-(3,5-difluorophenyl)-2-(3-(3-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-5-yl)propanamido)cyclohex-1-enecarboxylic acid | CHEMBL1084841 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H19F3N4O4 |
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| Mol. Mass. | 472.4166 |
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| SMILES | OC(=O)C1=C(CCC(C1)c1cc(F)cc(F)c1)NC(=O)CCc1nc(no1)-c1ccc(F)cn1 |t:3| |
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| Structure | 
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