Reaction Details |
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Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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Ligand | BDBM50319352 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_634029 (CHEMBL1118158) |
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IC50 | 1500±n/a nM |
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Citation | Webster, SP; Binnie, M; McConnell, KM; Sooy, K; Ward, P; Greaney, MF; Vinter, A; Pallin, TD; Dyke, HJ; Gill, MI; Warner, I; Seckl, JR; Walker, BR Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles. Bioorg Med Chem Lett20:3265-71 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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11-beta-hydroxysteroid dehydrogenase 1 |
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Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
Type: | Enzyme |
Mol. Mass.: | 32409.16 |
Organism: | Homo sapiens (Human) |
Description: | P28845 |
Residue: | 292 |
Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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BDBM50319352 |
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n/a |
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Name | BDBM50319352 |
Synonyms: | 3-[1-(1-adamantyl)-1H-tetrazol-5-yl]-1-phenylpropan-1-one | CHEMBL1083421 |
Type | Small organic molecule |
Emp. Form. | C21H25N3O |
Mol. Mass. | 335.4427 |
SMILES | O=C(CCc1cnnn1[C@@]12CC3CC(CC(C3)C1)C2)c1ccccc1 |r,TLB:8:9:12:16.14.15,THB:14:13:10:16.15.17,14:15:12.13.18:10,17:9:12:16.14.15,17:15:12:9.18.10| |
Structure |
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