Ki Summary

Reaction Details

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Target

Protein delta homolog 1

Ligand

BDBM50326053

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_655749

>10000±n/a nM

Citation

Zarrinkar PP; Gunawardane RN; Cramer MD; Gardner MF; Brigham D; Belli B; Karaman MW; Pratz KW; Pallares G; Chao Q; Sprankle KG; Patel HK; Levis M; Armstrong RC; James J; Bhagwat SS AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood 114:2984-92 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Protein delta homolog 1

Name:

Protein delta homolog 1

Synonyms:

DLK-1 | FA1 | Fetal antigen 1 | pG2

Type:

PROTEIN

Mol. Mass.:

41294.81

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1444684

Residue:

383

Sequence:

MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS
PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYS
GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE
NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT
GLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT
EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA
VNIIFPEKIDMTTFSKEAGDEEI

BDBM50326053

n/a

Name

BDBM50326053

Synonyms:

CHEMBL608533 | PKC-412

Type

Small organic molecule

Emp. Form.

C35H30N4O4

Mol. Mass.

570.6371

SMILES

CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 |r|

Structure