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TargetDelta-type opioid receptor
LigandBDBM50318666
Substrate/Competitorn/a
Meas. Tech.ChEMBL_658577
IC50>10000±n/a nM
Citation Rottmann MMcNamara CYeung BKLee MCZou BRussell BSeitz PPlouffe DMDharia NVTan JCohen SBSpencer KRGonzález-Páez GELakshminarayana SBGoh ASuwanarusk RJegla TSchmitt EKBeck HPBrun RNosten FRenia LDartois VKeller THFidock DAWinzeler EADiagana TT Spiroindolones, a potent compound class for the treatment of malaria. Science 329:1175-80 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Delta-type opioid receptor
Name:Opioid receptors; mu/kappa/delta
Synonyms:D-OR-1 | DOR-1 | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRK1 | opioid receptor, delta 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40382.98
Organism:Homo sapiens (Human)
Description:Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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  Blast E-value cutoff:
BDBM50318666
n/a
NameBDBM50318666
Synonyms:(1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-2,3,4,9-tetrahydrospiro-[beta-carboline-1,3'-indol]-2'(1'H)-one | CHEMBL1082723 | NITD609
TypeSmall organic molecule
Emp. Form.C19H14Cl2FN3O
Mol. Mass.390.238
SMILESC[C@H]1Cc2c([nH]c3cc(Cl)c(F)cc23)[C@@]2(N1)C(=O)Nc1ccc(Cl)cc21 |r|
Structure
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