Reaction Details |
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Target | G-protein coupled bile acid receptor 1 |
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Ligand | BDBM50327524 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_664648 (CHEMBL1260362) |
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IC50 | 710±n/a nM |
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Citation | Herbert, MR; Siegel, DL; Staszewski, L; Cayanan, C; Banerjee, U; Dhamija, S; Anderson, J; Fan, A; Wang, L; Rix, P; Shiau, AK; Rao, TS; Noble, SA; Heyman, RA; Bischoff, E; Guha, M; Kabakibi, A; Pinkerton, AB Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5. Bioorg Med Chem Lett20:5718-21 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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G-protein coupled bile acid receptor 1 |
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Name: | G-protein coupled bile acid receptor 1 |
Synonyms: | BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 35260.02 |
Organism: | Homo sapiens (Human) |
Description: | CHO cells transiently transfected with hTGR5. |
Residue: | 330 |
Sequence: | MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA
GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP
PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA
AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY
VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ
GLWGRASRDSPGPSIAYHPSSQSSVDLDLN
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BDBM50327524 |
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n/a |
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Name | BDBM50327524 |
Synonyms: | 2-(4-bromophenyl)-N-((2-(furan-3-yl)-7-methoxyquinolin-3-yl)methyl)ethanamine | CHEMBL1258531 |
Type | Small organic molecule |
Emp. Form. | C23H21BrN2O2 |
Mol. Mass. | 437.329 |
SMILES | COc1ccc2cc(CNCCc3ccc(Br)cc3)c(nc2c1)-c1ccoc1 |
Structure |
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