Reaction Details |
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Target | G-protein coupled bile acid receptor 1 |
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Ligand | BDBM50327530 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_664649 (CHEMBL1260363) |
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IC50 | >10000±n/a nM |
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Citation | Herbert, MR; Siegel, DL; Staszewski, L; Cayanan, C; Banerjee, U; Dhamija, S; Anderson, J; Fan, A; Wang, L; Rix, P; Shiau, AK; Rao, TS; Noble, SA; Heyman, RA; Bischoff, E; Guha, M; Kabakibi, A; Pinkerton, AB Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5. Bioorg Med Chem Lett20:5718-21 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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G-protein coupled bile acid receptor 1 |
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Name: | G-protein coupled bile acid receptor 1 |
Synonyms: | GPBAR_MOUSE | Gpbar1 | M-BAR | Membrane-type receptor for bile acids | Tgr5 |
Type: | PROTEIN |
Mol. Mass.: | 35665.78 |
Organism: | Mus musculus |
Description: | ChEMBL_1475560 |
Residue: | 329 |
Sequence: | MMTPNSTELSAIPMGVLGLSLALASLIVIANLLLALGIALDRHLRSPPAGCFFLSLLLAG
LLTGLALPMLPGLWSRNHQGYWSCLLLHLTPNFCFLSLLANLLLVHGERYMAVLQPLRPH
GSVRLALFLTWVSSLFFASLPALGWNHWSPDANCSSQAVFPAPYLYLEVYGLLLPAVGAT
ALLSVRVLATAHRQLCEIRRLERAVCRDVPSTLARALTWRQARAQAGATLLFLLCWGPYV
ATLLLSVLAYERRPPLGPGTLLSLISLGSTSAAAVPVAMGLGDQRYTAPWRTAAQRCLRV
LRGRAKRDNPGPSTAYHTSSQCSIDLDLN
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BDBM50327530 |
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n/a |
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Name | BDBM50327530 |
Synonyms: | 2-(4-bromophenyl)-N-((7-methoxy-2-(thiazol-2-yl)quinolin-3-yl)methyl)ethanamine | CHEMBL1258878 |
Type | Small organic molecule |
Emp. Form. | C22H20BrN3OS |
Mol. Mass. | 454.383 |
SMILES | COc1ccc2cc(CNCCc3ccc(Br)cc3)c(nc2c1)-c1nccs1 |
Structure |
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