| Reaction Details |
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 | Report a problem with these data |
| Target | Malonyl-CoA decarboxylase, mitochondrial |
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| Ligand | BDBM50328227 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_665405 (CHEMBL1261134) |
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| EC50 | 630±n/a nM |
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| Citation |  Tang, H; Yan, Y; Feng, Z; de Jesus, RK; Yang, L; Levorse, DA; Owens, KA; Akiyama, TE; Bergeron, R; Castriota, GA; Doebber, TW; Ellsworth, KP; Lassman, ME; Li, C; Wu, MS; Zhang, BB; Chapman, KT; Mills, SG; Berger, JP; Pasternak, A Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities. Bioorg Med Chem Lett20:6088-92 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Malonyl-CoA decarboxylase, mitochondrial |
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| Name: | Malonyl-CoA decarboxylase, mitochondrial |
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| Synonyms: | DCMC_MOUSE | MCD | Mlycd |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54752.52 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_665405 |
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| Residue: | 492 |
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| Sequence: | MRGLGPGLRARRLLPLRSPPRPPGPRGRRLCGGLAASAMDELLRRAVPPTPAYELREKTP
APAEGQCADFVSFYGGLAEASQRAELLGRLAQGFGVDHGQVAEQSAGVLQLRQQAREAAV
LLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPHVREMNGV
LKSMLSEWFSSGFLNLERVTWHSPCEVLQKISECEAVHPVKNWMDMKRRVGPYRRCYFFS
HCSTPGEPLVVLHVALTGDISNNIQGIVKECPPTETEERNRIAAAIFYSISLTQQGLQGV
ELGTFLIKRVVKELQKEFPQLGAFSSLSPIPGFTKWLLGLLNVQGKEHGRNELFTDSECQ
EISAVTGNPVHESLKGFLSSGEWVKSEKLTQALQGPLMRLCAWYLYGEKHRGYALNPVAN
FHLQNGAVMWRINWMADSSLKGLTSSCGLMVNYRYYLEETGPNSISYLGSKNIKASEQIL
SLVAQFQNNSKL
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| BDBM50328227 |
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| n/a |
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| Name | BDBM50328227 |
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| Synonyms: | 3-(4-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)thiazol-2-yl)piperazin-1-yl)-N-methylbenzamide | CHEMBL1258936 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18F6N4O2S |
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| Mol. Mass. | 468.417 |
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| SMILES | CNC(=O)c1cccc(c1)N1CCN(CC1)c1ncc(s1)C(O)(C(F)(F)F)C(F)(F)F |
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| Structure | 
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