| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal Pro-X carboxypeptidase |
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| Ligand | BDBM50328539 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_665678 (CHEMBL1261609) |
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| IC50 | 7±n/a nM |
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| Citation |  Zhou, C; Garcia-Calvo, M; Pinto, S; Lombardo, M; Feng, Z; Bender, K; Pryor, KD; Bhatt, UR; Chabin, RM; Geissler, WM; Shen, Z; Tong, X; Zhang, Z; Wong, KK; Roy, RS; Chapman, KT; Yang, L; Xiong, Y Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity. J Med Chem53:7251-63 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal Pro-X carboxypeptidase |
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| Name: | Lysosomal Pro-X carboxypeptidase |
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| Synonyms: | Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55805.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P42785 |
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| Residue: | 496 |
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| Sequence: | MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHF
GFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFA
EHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSY
GGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRS
WDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQP
LPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWS
YQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHT
NIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRH
MKNWIRDFYDSAGKQH
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| BDBM50328539 |
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| n/a |
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| Name | BDBM50328539 |
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| Synonyms: | 2-Amino-N-{(2S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5-tert-butyl-1Himidazol-2-yl)pyrrolidin-1-yl]-1-oxopropan-2-yl}-2-methylpropanamide | CHEMBL1259178 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H39N5O2 |
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| Mol. Mass. | 501.663 |
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| SMILES | CC(C)(C)c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)C(C)(C)N |r| |
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| Structure | 
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