| Reaction Details |
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 | Report a problem with these data |
| Target | TGF-beta receptor type-2 |
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| Ligand | BDBM50279164 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_674818 (CHEMBL1274126) |
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| IC50 | 19000±n/a nM |
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| Citation |  Roth, GJ; Heckel, A; Brandl, T; Grauert, M; Hoerer, S; Kley, JT; Schnapp, G; Baum, P; Mennerich, D; Schnapp, A; Park, JE Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factorß receptor I (TGFßRI). J Med Chem53:7287-95 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| TGF-beta receptor type-2 |
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| Name: | TGF-beta receptor type-2 |
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| Synonyms: | TGF-beta receptor type II | TGFBR2 | TGFR2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64559.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586859 |
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| Residue: | 567 |
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| Sequence: | MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFST
CDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPK
CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI
SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTE
LLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLK
HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH
LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG
TARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVRE
HPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSE
LEHLDRLSGRSCSEEKIPEDGSLNTTK
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| BDBM50279164 |
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| n/a |
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| Name | BDBM50279164 |
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| Synonyms: | (3Z)-N-ETHYL-N-METHYL-2-OXO-3-(PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]AMINO}METHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-6-CARBOXAMIDE | (Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic Acid Ethylmethylamide | CHEMBL496862 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H34N4O2 |
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| Mol. Mass. | 494.6273 |
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| SMILES | CCN(C)C(=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1 |w:12.12| |
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| Structure | 
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