Reaction Details |
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Target | Bile acid receptor |
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Ligand | BDBM50334245 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_699400 (CHEMBL1647427) |
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IC50 | 3800±n/a nM |
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Citation | Richter, HG; Benson, GM; Blum, D; Chaput, E; Feng, S; Gardes, C; Grether, U; Hartman, P; Kuhn, B; Martin, RE; Plancher, JM; Rudolph, MG; Schuler, F; Taylor, S; Bleicher, KH Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia& diabetes. Bioorg Med Chem Lett21:191-4 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bile acid receptor |
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Name: | Bile acid receptor |
Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor |
Type: | Nuclear Receptor |
Mol. Mass.: | 55916.24 |
Organism: | Homo sapiens (Human) |
Description: | Q96RI1 |
Residue: | 486 |
Sequence: | MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYS
NVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTK
KPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCV
MDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEG
RDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLI
LTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSD
LLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK
LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLC
EIWDVQ
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BDBM50334245 |
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n/a |
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Name | BDBM50334245 |
Synonyms: | 2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-N-cyclohexyl-2-(tetrahydro-2H-pyran-4-yl)acetamide | CHEMBL1642351 |
Type | Small organic molecule |
Emp. Form. | C26H30ClN3O2 |
Mol. Mass. | 451.988 |
SMILES | Clc1ccc(cc1)-c1nc2ccccc2n1C(C1CCOCC1)C(=O)NC1CCCCC1 |
Structure |
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