| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 3 |
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| Ligand | BDBM50337218 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_726359 (CHEMBL1687491) |
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| IC50 | 6.7±n/a nM |
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| Citation |  Shao, Y; Anilkumar, GN; Carroll, CD; Dong, G; Hall, JW; Hobbs, DW; Jiang, Y; Jenh, CH; Kim, SH; Kozlowski, JA; McGuinness, BF; Rosenblum, SB; Schulman, I; Shih, NY; Shu, Y; Wong, MK; Yu, W; Zawacki, LG; Zeng, Q II. SAR studies of pyridyl-piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists. Bioorg Med Chem Lett21:1527-31 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 3 |
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| Name: | C-X-C chemokine receptor type 3 |
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| Synonyms: | CXCR3_MOUSE | Cmkar3 | Cxcr3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41020.84 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_560734 |
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| Residue: | 367 |
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| Sequence: | MYLEVSERQVLDASDFAFLLENSTSPYDYGENESDFSDSPPCPQDFSLNFDRTFLPALYS
LLFLLGLLGNGAVAAVLLSQRTALSSTDTFLLHLAVADVLLVLTLPLWAVDAAVQWVFGP
GLCKVAGALFNINFYAGAFLLACISFDRYLSIVHATQIYRRDPRVRVALTCIVVWGLCLL
FALPDFIYLSANYDQRLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAV
LLVSRGQRRFRAMRLVVVVVAAFAVCWTPYHLVVLVDILMDVGVLARNCGRESHVDVAKS
VTSGMGYMHCCLNPLLYAFVGVKFREQMWMLFTRLGRSDQRGPQRQPSSSRRESSWSETT
EASYLGL
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| BDBM50337218 |
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| n/a |
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| Name | BDBM50337218 |
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| Synonyms: | (S)-5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-methylpiperazin-1-yl)-N-(3,4-difluorobenzyl)nicotinamide | CHEMBL1681849 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H33Cl2F2N5O |
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| Mol. Mass. | 588.519 |
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| SMILES | C[C@H]1CN(CCN1C1CCN(Cc2ccc(Cl)cc2)CC1)c1ncc(cc1Cl)C(=O)NCc1ccc(F)c(F)c1 |r| |
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| Structure | 
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