Ki Summary

Reaction Details

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Target

C-X-C chemokine receptor type 3

Ligand

BDBM50337251

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_726359 (CHEMBL1687491)

IC50

1.1±n/a nM

Citation

Shao, Y; Anilkumar, GN; Carroll, CD; Dong, G; Hall, JW; Hobbs, DW; Jiang, Y; Jenh, CH; Kim, SH; Kozlowski, JA; McGuinness, BF; Rosenblum, SB; Schulman, I; Shih, NY; Shu, Y; Wong, MK; Yu, W; Zawacki, LG; Zeng, Q II. SAR studies of pyridyl-piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists. Bioorg Med Chem Lett21:1527-31 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

C-X-C chemokine receptor type 3

Name:

C-X-C chemokine receptor type 3

Synonyms:

CXCR3_MOUSE | Cmkar3 | Cxcr3

Type:

PROTEIN

Mol. Mass.:

41020.84

Organism:

Mus musculus

Description:

ChEMBL_560734

Residue:

367

Sequence:

MYLEVSERQVLDASDFAFLLENSTSPYDYGENESDFSDSPPCPQDFSLNFDRTFLPALYS
LLFLLGLLGNGAVAAVLLSQRTALSSTDTFLLHLAVADVLLVLTLPLWAVDAAVQWVFGP
GLCKVAGALFNINFYAGAFLLACISFDRYLSIVHATQIYRRDPRVRVALTCIVVWGLCLL
FALPDFIYLSANYDQRLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAV
LLVSRGQRRFRAMRLVVVVVAAFAVCWTPYHLVVLVDILMDVGVLARNCGRESHVDVAKS
VTSGMGYMHCCLNPLLYAFVGVKFREQMWMLFTRLGRSDQRGPQRQPSSSRRESSWSETT
EASYLGL

BDBM50337251

n/a

Name

BDBM50337251

Synonyms:

(S)-5-chloro-6-(4-(1-(4-chloro-2-fluorobenzyl)piperidin-4-yl)-3-ethylpiperazin-1-yl)-N-ethylnicotinamide | CHEMBL1681882

Type

Small organic molecule

Emp. Form.

C26H34Cl2FN5O

Mol. Mass.

522.485

SMILES

CCNC(=O)c1cnc(N2CCN([C@@H](CC)C2)C2CCN(Cc3ccc(Cl)cc3F)CC2)c(Cl)c1 |r|

Structure