Reaction Details | |||
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Target | Insulin receptor | ||
Ligand | BDBM50339062 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_729928 (CHEMBL1695282) | ||
IC50 | 48±n/a nM | ||
Citation | Jin, M; Gokhale, PC; Cooke, A; Foreman, K; Buck, E; May, EW; Feng, L; Bittner, MA; Kadalbajoo, M; Landfair, D; Siu, KW; Stolz, KM; Werner, DS; Laufer, RS; Li, AH; Dong, H; Steinig, AG; Kleinberg, A; Yao, Y; Pachter, JA; Wild, R; Mulvihill, MJ Discovery of an Orally Efficacious Imidazo[5,1-f][1,2,4]triazine Dual Inhibitor of IGF-1R and IR. ACS Med Chem Lett1:510-515 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Insulin receptor | |||
Name: | Insulin receptor | ||
Synonyms: | INSR | INSR protein | INSR_HUMAN | Insulin receptor (IR) | Insulin receptor beta subunit | ||
Type: | Receptor Tyrosine Kinase | ||
Mol. Mass.: | 156322.60 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P06213 | ||
Residue: | 1382 | ||
Sequence: |
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BDBM50339062 | |||
n/a | |||
Name | BDBM50339062 | ||
Synonyms: | 4-(3-(4-amino-5-(8-fluoro-2-phenylquinolin-7-yl)imidazo[1,5-f][1,2,4]triazin-7-yl)cyclobutyl)piperazine-1-carbaldehyde | CHEMBL1688361 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H27FN8O | ||
Mol. Mass. | 522.5761 | ||
SMILES | Nc1ncnn2c(nc(-c3ccc4ccc(nc4c3F)-c3ccccc3)c12)[C@@H]1C[C@@H](C1)N1CCN(CC1)C=O |r,wU:27.31,29.36,(5.56,-13.24,;5.57,-14.78,;4.24,-15.55,;4.24,-17.09,;5.57,-17.86,;6.9,-17.08,;8.37,-17.56,;9.28,-16.31,;8.37,-15.06,;9.12,-13.72,;8.34,-12.4,;9.1,-11.06,;10.64,-11.05,;11.4,-9.71,;12.94,-9.7,;13.72,-11.04,;12.95,-12.37,;11.41,-12.38,;10.67,-13.71,;11.45,-15.04,;15.25,-11.03,;16.03,-12.36,;17.57,-12.35,;18.33,-11.01,;17.55,-9.68,;16.01,-9.69,;6.9,-15.54,;8.84,-19.01,;8.14,-20.39,;9.52,-21.09,;10.21,-19.71,;10,-22.55,;8.96,-23.7,;9.43,-25.15,;10.94,-25.48,;11.97,-24.34,;11.5,-22.87,;11.41,-26.95,;10.37,-28.09,)| | ||
Structure |