| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase Mdm2 |
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| Ligand | BDBM50339357 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_736488 (CHEMBL1694433) |
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| IC50 | 900±n/a nM |
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| Citation |  Hardcastle, IR; Liu, J; Valeur, E; Watson, A; Ahmed, SU; Blackburn, TJ; Bennaceur, K; Clegg, W; Drummond, C; Endicott, JA; Golding, BT; Griffin, RJ; Gruber, J; Haggerty, K; Harrington, RW; Hutton, C; Kemp, S; Lu, X; McDonnell, JM; Newell, DR; Noble, ME; Payne, SL; Revill, CH; Riedinger, C; Xu, Q; Lunec, J Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency. J Med Chem54:1233-43 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase Mdm2 |
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| Name: | E3 ubiquitin-protein ligase Mdm2 |
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| Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
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| Type: | Oncoprotein |
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| Mol. Mass.: | 55196.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00987 |
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| Residue: | 491 |
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| Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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| BDBM50339357 |
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| n/a |
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| Name | BDBM50339357 |
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| Synonyms: | (+/-)-(S)-3-(4-Chlorophenyl)-2-[1-(4-chlorophenyl)ethyl]-3-(4-hydroxybutoxy)-2,3-dihydroisoindol-1-one | CHEMBL1688262 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25Cl2NO3 |
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| Mol. Mass. | 470.388 |
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| SMILES | C[C@H](N1C(=O)c2ccccc2C1(OCCCCO)c1ccc(Cl)cc1)c1ccc(Cl)cc1 |r| |
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| Structure | 
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