| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glucose-dependent insulinotropic receptor |
|---|
| Ligand | BDBM50342686 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_745193 (CHEMBL1772424) |
|---|
| EC50 | 48±n/a nM |
|---|
| Citation |  Szewczyk, JW; Acton, J; Adams, AD; Chicchi, G; Freeman, S; Howard, AD; Huang, Y; Li, C; Meinke, PT; Mosely, R; Murphy, E; Samuel, R; Santini, C; Yang, M; Zhang, Y; Zhao, K; Wood, HB Design of potent and selective GPR119 agonists for type II diabetes. Bioorg Med Chem Lett21:2665-9 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glucose-dependent insulinotropic receptor |
|---|
| Name: | Glucose-dependent insulinotropic receptor |
|---|
| Synonyms: | G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 36901.49 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q8TDV5 |
|---|
| Residue: | 335 |
|---|
| Sequence: | MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISG
LLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGF
VAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLL
FVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTP
FLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKV
LTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
|
|
|
|---|
| BDBM50342686 |
|---|
| n/a |
|---|
| Name | BDBM50342686 |
|---|
| Synonyms: | 1-(5-chloropyridin-2-yl)-1'-(4-(methylsulfonyl)phenyl)-4,4'-bipiperidine | CHEMBL1771088 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H28ClN3O2S |
|---|
| Mol. Mass. | 433.995 |
|---|
| SMILES | CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccc(Cl)cn1 |
|---|
| Structure | 
|
|---|
Search and Browse
