| Reaction Details |
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 | Report a problem with these data |
| Target | Cholinesterase |
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| Ligand | BDBM50342759 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_744406 (CHEMBL1772360) |
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| IC50 | 708±n/a nM |
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| Citation |  Li, YP; Ning, FX; Yang, MB; Li, YC; Nie, MH; Ou, TM; Tan, JH; Huang, SL; Li, D; Gu, LQ; Huang, ZS Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation. Eur J Med Chem46:1572-81 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholinesterase |
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| Name: | Cholinesterase |
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| Synonyms: | BCHE | Butyrylcholinesterase (BuChE) | CHLE_HORSE | Cholinesterase |
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| Type: | Enzyme |
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| Mol. Mass.: | 65643.35 |
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| Organism: | Equus caballus (Horse) |
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| Description: | P81908 |
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| Residue: | 574 |
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| Sequence: | EEDIIITTKNGKVRGMNLPVLGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSNIWNATK
YANSCYQNTDQSFPGFLGSEMWNPNTELSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQT
GTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLALSENPEAPGNMGLFDQQLALQWVQK
NIAAFGGNPRSVTLFGESAGAASVSLHLLSPRSQPLFTRAILQSGSSNAPWAVTSLYEAR
NRTLTLAKRMGCSRDNETEMIKCLRDKDPQEILLNEVFVVPYDTLLSVNFGPTVDGDFLT
DMPDTLLQLGQFKRTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPR
VSEFGRESILFHYMDWLDDQRAENYREALDDVVGDYNIICPALEFTRKFSELGNDAFFYY
FEHRSTKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEILSRSIMKRWANFAKYGNP
NGTQNNSTRWPVFKSTEQKYLTLNTESPKVYTKLRAQQCRFWTLFFPKVLELTGNIDEAE
REWKAGFHRWNNYMMDWKNQFNDYTSKKESCSDF
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| BDBM50342759 |
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| n/a |
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| Name | BDBM50342759 |
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| Synonyms: | CHEMBL1770197 | N,N-diethyl-N-methyl-2-(7-oxo-7H-dibenzo[de,h]quinolin-3-yloxy)ethanaminium iodide |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25N2O2 |
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| Mol. Mass. | 361.4563 |
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| SMILES | CC[N+](C)(CC)CCOc1cnc2-c3ccccc3C(=O)c3cccc1c23 |
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| Structure | 
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