| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 10 |
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| Ligand | BDBM50345610 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_751380 (CHEMBL1785341) |
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| IC50 | >50000±n/a nM |
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| Citation |  Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement. Bioorg Med Chem Lett21:3726-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 10 |
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| Name: | Mitogen-activated protein kinase 10 |
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| Synonyms: | JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52586.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 464 |
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| Sequence: | MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
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| BDBM50345610 |
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| n/a |
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| Name | BDBM50345610 |
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| Synonyms: | 3-(pyridin-4-yl)-4-(quinolin-3-yl)-1H-1,2,4-triazole-5(4H)-thione | CHEMBL1784643 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11N5S |
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| Mol. Mass. | 305.357 |
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| SMILES | S=c1[nH]nc(-c2ccncc2)n1-c1cnc2ccccc2c1 |
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| Structure | 
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