Reaction Details |
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Target | Cholinesterase |
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Ligand | BDBM50346438 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_751135 (CHEMBL1787217) |
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IC50 | 930±n/a nM |
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Citation | Tasso, B; Catto, M; Nicolotti, O; Novelli, F; Tonelli, M; Giangreco, I; Pisani, L; Sparatore, A; Boido, V; Carotti, A; Sparatore, F Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease. Eur J Med Chem46:2170-84 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cholinesterase |
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Name: | Cholinesterase |
Synonyms: | BCHE | Butyrylcholinesterase (BuChE) | CHLE_HORSE | Cholinesterase |
Type: | Enzyme |
Mol. Mass.: | 65643.35 |
Organism: | Equus caballus (Horse) |
Description: | P81908 |
Residue: | 574 |
Sequence: | EEDIIITTKNGKVRGMNLPVLGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSNIWNATK
YANSCYQNTDQSFPGFLGSEMWNPNTELSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQT
GTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLALSENPEAPGNMGLFDQQLALQWVQK
NIAAFGGNPRSVTLFGESAGAASVSLHLLSPRSQPLFTRAILQSGSSNAPWAVTSLYEAR
NRTLTLAKRMGCSRDNETEMIKCLRDKDPQEILLNEVFVVPYDTLLSVNFGPTVDGDFLT
DMPDTLLQLGQFKRTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPR
VSEFGRESILFHYMDWLDDQRAENYREALDDVVGDYNIICPALEFTRKFSELGNDAFFYY
FEHRSTKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEILSRSIMKRWANFAKYGNP
NGTQNNSTRWPVFKSTEQKYLTLNTESPKVYTKLRAQQCRFWTLFFPKVLELTGNIDEAE
REWKAGFHRWNNYMMDWKNQFNDYTSKKESCSDF
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BDBM50346438 |
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n/a |
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Name | BDBM50346438 |
Synonyms: | (1S,9aR)-1-((9H-thioxanthen-9-ylidene)methyl)octahydro-1H-quinolizine | CHEMBL1782721 |
Type | Small organic molecule |
Emp. Form. | C23H25NS |
Mol. Mass. | 347.516 |
SMILES | [#6]-1-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6@@H](\[#6]=[#6]-3\c4ccccc4-[#16]-c4ccccc-34)-[#6@H]-2-[#6]-1 |r| |
Structure |
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