| Reaction Details |
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 | Report a problem with these data |
| Target | Type-2 angiotensin II receptor |
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| Ligand | BDBM50347563 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_757052 (CHEMBL1803893) |
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| Ki | >10000±n/a nM |
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| Citation |  Casimiro-Garcia, A; Filzen, GF; Flynn, D; Bigge, CF; Chen, J; Davis, JA; Dudley, DA; Edmunds, JJ; Esmaeil, N; Geyer, A; Heemstra, RJ; Jalaie, M; Ohren, JF; Ostroski, R; Ellis, T; Schaum, RP; Stoner, C Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-¿. J Med Chem54:4219-33 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-2 angiotensin II receptor |
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| Name: | Type-2 angiotensin II receptor |
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| Synonyms: | AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41201.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Angiotensin II, central 0 0::P50052 |
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| Residue: | 363 |
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| Sequence: | MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFL
VNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMET
FVS
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| BDBM50347563 |
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| n/a |
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| Name | BDBM50347563 |
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| Synonyms: | CHEMBL1801740 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31N7 |
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| Mol. Mass. | 477.6033 |
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| SMILES | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(ccc12)-c1ccccc1-c1nnn[nH]1 |r| |
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| Structure | 
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