Reaction Details |
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Target | Glycogen synthase kinase-3 beta |
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Ligand | BDBM50354756 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_771509 (CHEMBL1837408) |
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IC50 | 45±n/a nM |
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Citation | Cociorva, OM; Li, B; Nomanbhoy, T; Li, Q; Nakamura, A; Nakamura, K; Nomura, M; Okada, K; Seto, S; Yumoto, K; Liyanage, M; Zhang, MC; Aban, A; Leen, B; Szardenings, AK; Rosenblum, JS; Kozarich, JW; Kohno, Y; Shreder, KR Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3ß. Bioorg Med Chem Lett21:5948-51 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen synthase kinase-3 beta |
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Name: | Glycogen synthase kinase-3 beta |
Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
Type: | Enzyme |
Mol. Mass.: | 46756.38 |
Organism: | Homo sapiens (Human) |
Description: | P49841 |
Residue: | 420 |
Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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BDBM50354756 |
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n/a |
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Name | BDBM50354756 |
Synonyms: | CHEMBL1834117 |
Type | Small organic molecule |
Emp. Form. | C19H19F2N5O3 |
Mol. Mass. | 403.3827 |
SMILES | Nc1c(F)c(NCCCn2ccnc2)c(F)c2n(cc(C(O)=O)c(=O)c12)C1CC1 |
Structure |
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