| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta |
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| Ligand | BDBM50354777 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_771509 (CHEMBL1837408) |
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| IC50 | 160±n/a nM |
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| Citation |  Cociorva, OM; Li, B; Nomanbhoy, T; Li, Q; Nakamura, A; Nakamura, K; Nomura, M; Okada, K; Seto, S; Yumoto, K; Liyanage, M; Zhang, MC; Aban, A; Leen, B; Szardenings, AK; Rosenblum, JS; Kozarich, JW; Kohno, Y; Shreder, KR Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3ß. Bioorg Med Chem Lett21:5948-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta |
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| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
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| Type: | Enzyme |
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| Mol. Mass.: | 46756.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49841 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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| BDBM50354777 |
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| n/a |
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| Name | BDBM50354777 |
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| Synonyms: | CHEMBL1834328 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24FN5O4 |
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| Mol. Mass. | 441.4555 |
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| SMILES | CC1(C)COc2c(NCCNc3ccccn3)c(F)c(N)c3c2n(C1)cc(C(O)=O)c3=O |
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| Structure | 
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